Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21548844 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1LMNAENPP1MAPT | |
| SCHEMBL21548960 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TP53TDP1ENPP1 | |
| SCHEMBL23956006 | 0.82 | MAPK14 (0.39) | SMN1; SMN2ALDH1A1LMNAENPP1HPGD | |
| SCHEMBL20356576 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1L3MBTL1TP53LMNA | |
| SCHEMBL20356567 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1L3MBTL1TP53LMNA | |
| SCHEMBL20356707 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TP53LMNATDP1 | |
| SCHEMBL21526079 | 0.74 | GPR132 (0.44) | SMN1; SMN2ALDH1A1L3MBTL1TP53LMNA | |
| SCHEMBL21548830 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1L3MBTL1LMNAENPP1 | |
| SCHEMBL20356709 | 0.73 | NR4A2 (0.42) | SMN1; SMN2ALDH1A1TP53LMNATDP1 | |
| SCHEMBL23956005 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1L3MBTL1LMNAENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |