Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | MGMT | P16455 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23956006 | 0.91 | MAPK14 (0.39) | SMN1; SMN2ALDH1A1ENPP1HTR2AHTR2C | |
| SCHEMBL21548812 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1ENPP1MAPTMCL1 | |
| SCHEMBL20356708 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1ENPP1MAPTPTGER1 | |
| SCHEMBL21548844 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1ENPP1MGMTTLR8 | |
| SCHEMBL21526008 | 0.74 | PTGER1 (0.43) | SMN1; SMN2ALDH1A1MAPTPTGER1HPGD | |
| SCHEMBL21548830 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1ENPP1MAPTKDM4E | |
| SCHEMBL20356707 | 0.69 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1ENPP1MAPTPTGER1 | |
| SCHEMBL21548807 | 0.69 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1ENPP1MAPTKDM4E | |
| SCHEMBL20356576 | 0.69 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1ENPP1MAPTPTGER1 | |
| SCHEMBL21525997 | 0.68 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1ENPP1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |