Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21549540 | 1.00 | TP53 (0.46) | TP53PKMKCNH2PAX8HDAC6 | |
| SCHEMBL25457426 | 0.92 | KCNH2 (0.46) | KCNH2HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL21549538 | 0.90 | FTO (0.48) | TP53PKMKCNH2PAX8ALDH1A1 | |
| SCHEMBL25457289 | 0.90 | MEN1 (0.44) | TP53PKMKCNH2PAX8HDAC6 | |
| SCHEMBL20353098 | 0.88 | KCNH2 (0.44) | KCNH2HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL25457273 | 0.87 | HTT (0.52) | TP53PKMKCNH2PAX8ALDH1A1 | |
| SCHEMBL25457277 | 0.86 | FTO (0.45) | TP53KCNH2PAX8NT5EALB | |
| SCHEMBL25457276 | 0.86 | FTO (0.45) | TP53KCNH2PAX8NT5EALB | |
| SCHEMBL21549533 | 0.84 | KCNH2 (0.43) | KCNH2HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL26832927 | 0.83 | FTO (0.50) | KCNH2PAX8ALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382908-A1 | NANOLUC SUICIDE SUBSTRATES | PROMEGA CORPORATION | 2023-11-30 | — | — | US | disclosed |
| US-20230382908-A1 | NANOLUC SUICIDE SUBSTRATES | PROMEGA CORPORATION | 2023-11-30 | — | — | US | disclosed |
| US-11655247-B2 | Nanoluc suicide substrates | PROMEGA CORPORATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-11655247-B2 | Nanoluc suicide substrates | PROMEGA CORPORATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-20190337939-A1 | NANOLUC SUICIDE SUBSTRATES | PROMEGA CORPORATION | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382908-A1 | NANOLUC SUICIDE SUBSTRATES | XIAP, NLN, BAD | TP53 2514/4885PKM 1879/4885KCNH2 3345/4885 |
| US-11655247-B2 | Nanoluc suicide substrates | XIAP, NLN, BAD | TP53 2514/4885PKM 1879/4885KCNH2 3345/4885 |
| US-20190337939-A1 | NANOLUC SUICIDE SUBSTRATES | XIAP, NLN, BAD | TP53 2514/4885PKM 1879/4885KCNH2 3345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.