SCHEMBL21550140

SCHEMBL21550140

O=C(c1ccc(CBr)cc1Br)c1ccc(F)cc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.42
ATM Q13315 1/20 0.42
CYP3A4 P08684 1/20 0.36
NR3C1 P04150 2/20 0.36
CES2 O00748 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
CNR2 P34972 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HCRTR1 O43613 1/20 0.34
HCRTR2 O43614 1/20 0.34
VNN1 O95497 1/20 0.33
IDO1 P14902 1/20 0.33
GPR183 P32249 1/20 0.33
EPHX2 P34913 1/20 0.33
PPARG P37231 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20157777 0.83 CES2 (0.47) KMT2ANR3C1CES2
SCHEMBL21550074 0.83 KMT2A (0.40) KMT2AATMCYP3A4NR3C1CES2
SCHEMBL21564849 0.81 KMT2A (0.46) KMT2AATMCES2HCRTR1HCRTR2
SCHEMBL21352128 0.81 HPGD (0.43) NR3C1
SCHEMBL28462767 0.81 KMT2A (0.55) KMT2AATMCYP3A4CES2MRGPRX4
SCHEMBL20157850 0.80 MAPT (0.39) KMT2ACES2
SCHEMBL20157560 0.79 PTPN1 (0.43) KMT2ACES2HDAC3HDAC1HDAC2
SCHEMBL21550083 0.78 KMT2A (0.42) KMT2AATMCYP3A4CES2MRGPRX4
SCHEMBL20157512 0.77 NPC1 (0.46) KMT2ANR3C1
SCHEMBL3661976 0.75 CES2 (0.44) CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019214399-A1 BENZO- SEVEN-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF 罗欣药业(上海)有限公司 (CN) 2019-11-14 WO disclosed
WO-2019214399-A1 BENZO- SEVEN-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF 罗欣药业(上海)有限公司 (CN) 2019-11-14 WO disclosed