Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157334 | 0.80 | PRMT5 (0.48) | PRMT5WDR77AAK1HIF1A | |
| SCHEMBL28900799 | 0.79 | ALDH1A1 (0.35) | PRMT5WDR77 | |
| SCHEMBL21351864 | 0.77 | PRMT5 (0.32) | PRMT5WDR77AAK1HIF1A | |
| SCHEMBL21354493 | 0.76 | HIF1A (0.32) | PRMT5WDR77HIF1A | |
| SCHEMBL20520066 | 0.75 | ATAD2 (0.37) | PRMT5WDR77HIF1A | |
| SCHEMBL21550013 | 0.74 | ACHE (0.33) | PRMT5WDR77AAK1 | |
| SCHEMBL21550012 | 0.73 | AAK1 (0.38) | PRMT5WDR77AAK1HIF1A | |
| SCHEMBL28474075 | 0.73 | BAZ2B (0.33) | — | |
| SCHEMBL21352096 | 0.71 | HIF1A (0.30) | HIF1A | |
| SCHEMBL18301350 | 0.69 | ATAD2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019214399-A1 | BENZO- SEVEN-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | 罗欣药业(上海)有限公司 (CN) | 2019-11-14 | — | — | WO | disclosed |