Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL778555 | 0.73 | HPGD (0.44) | HPGDSMN1; SMN2THRBELANEPLAU | |
| SCHEMBL8955453 | 0.71 | PTPN1 (0.48) | HPGDSMN1; SMN2ALDH1A1ALOX12ELANE | |
| SCHEMBL778035 | 0.69 | HPGD (0.41) | HPGDSMN1; SMN2ALDH1A1ALOX12ELANE | |
| SCHEMBL2155113 | 0.69 | PGK1 (0.36) | HPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL28567265 | 0.67 | CES1 (0.42) | HPGDKMT2ASMN1; SMN2MAPTTHRB | |
| SCHEMBL777436 | 0.67 | HPGD (0.42) | HPGDKMT2ASMN1; SMN2THRBALDH1A1 | |
| SCHEMBL29424792 | 0.67 | HPGD (0.48) | HPGDKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL697168 | 0.67 | HPGD (0.48) | HPGDKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29792964 | 0.67 | HPGD (0.48) | HPGDKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30281296 | 0.67 | HPGD (0.48) | HPGDKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519100-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | Mapi Pharma Limited (IL) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080736-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA HK LIMITED (CN) | 2011-07-07 | — | — | WO | disclosed |