Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.42 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191716 | 0.80 | PDE3B (0.41) | PGRNR3C2NR3C1IL4I1PDE3B | |
| SCHEMBL25277194 | 0.79 | PGR (0.41) | PGRNR3C2NR3C1IL4I1PDE3B | |
| SCHEMBL27433477 | 0.79 | PDE3B (0.44) | PGRNR3C2NR3C1IL4I1PDE3B | |
| SCHEMBL4290482 | 0.78 | IL4I1 (0.44) | PGRNR3C2NR3C1IL4I1PDE3B | |
| SCHEMBL30183935 | 0.74 | PDE3B (0.36) | PGRNR3C2NR3C1PDE3BPDE3A | |
| SCHEMBL23591044 | 0.74 | PDE3B (0.36) | PGRNR3C2NR3C1PDE3BPDE3A | |
| SCHEMBL4480236 | 0.73 | PDE3B (0.41) | PGRNR3C2NR3C1IL4I1PDE3B | |
| SCHEMBL21552373 | 0.73 | PGR (0.45) | PGRNR3C2NR3C1IL4I1PDE3B | |
| SCHEMBL4102483 | 0.73 | NR3C2 (0.45) | PGRNR3C2NR3C1PDE3BPDE3A | |
| SCHEMBL29939223 | 0.73 | NR3C2 (0.45) | PGRNR3C2NR3C1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3790551-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-03-17 | — | — | EP | disclosed |
| WO-2019217307-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-11-14 | — | — | WO | disclosed |
| WO-2019217307-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-11-14 | — | — | WO | disclosed |