SCHEMBL21553091

SCHEMBL21553091

CC(C)(C)[Si](C)(C)OCCCc1cn(Cc2ccc(F)cc2)c(=O)c(N2CCS(O)(O)CC2)n1

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SRC P12931 3/20 0.33
FLT3 P36888 3/20 0.33
FYN P06241 2/20 0.33
DUT P33316 1/20 0.33
FSCN1 Q16658 1/20 0.32
HDAC6 Q9UBN7 9/20 0.32
HTR2A P28223 1/20 0.32
MCHR1 Q99705 1/20 0.32
SOS1 Q07889 1/20 0.31
PIK3CA P42336 2/20 0.31
PIK3CD O00329 1/20 0.31
PIK3CB P42338 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21553093 0.92 ALDH1A1 (0.36) SRCFLT3FYNDUTFSCN1
SCHEMBL21552861 0.87 GAA (0.39) HDAC6HTR2AMCHR1
SCHEMBL21553080 0.85 KDM1A (0.36) SRCFLT3FYNDUTSOS1
SCHEMBL29156945 0.82 FPR2 (0.37)
SCHEMBL21553001 0.81 SRC (0.33) SRCFLT3FYNHDAC6SOS1
SCHEMBL23258789 0.79 ALDH1A1 (0.40) SRCFLT3FYNFSCN1HDAC6
SCHEMBL21552820 0.78 ALDH1A1 (0.35) SRCFLT3FYNFSCN1HDAC6
SCHEMBL21552941 0.76 PDE1B (0.38) DUTPIK3CA
SCHEMBL21564673 0.75 CYP11B1 (0.42) SRCFLT3FYNFSCN1HDAC6
SCHEMBL21552935 0.75 CNR2 (0.39) SRCFLT3FYNHDAC6SOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790867-B1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES INC (US) 2024-03-27 EP disclosed
US-11932629-B2 KDM1A inhibitors for the treatment of disease IMAGO BIOSCIENCES, INC. (US) 2024-03-19 US disclosed
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES INC (US) 2023-08-10 US disclosed
US-11578059-B2 KDM1A inhibitors for the treatment of disease Imago Biosciences. Inc. (US) 2023-02-14 US disclosed
US-20210115023-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2021-04-22 US disclosed
EP-3790867-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE Imago Biosciences Inc. (US) 2021-03-17 EP disclosed
WO-2019217972-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. (US) 2019-11-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11932629-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A SRC 2429/4885FLT3 1454/4885FYN 3776/4885
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A SRC 2429/4885FLT3 1454/4885FYN 3776/4885
US-20210115023-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1A, KDM1B, KDM2A SRC 2381/4885FLT3 1179/4885FYN 3575/4885
US-11578059-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A SRC 2429/4885FLT3 1454/4885FYN 3776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.