Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19277912 | 0.83 | MAPT (0.38) | MAPTALDH1A1KDM4ETHRBALOX15 | |
| SCHEMBL30493611 | 0.83 | GNPAT (0.39) | MAPTALDH1A1OPRM1SIRT6SIRT1 | |
| SCHEMBL27263098 | 0.82 | ACE (0.35) | ALDH1A1THRBFCER2TLR2 | |
| SCHEMBL30493797 | 0.80 | SIRT6 (0.42) | MAPTALDH1A1OPRM1SIRT6SIRT1 | |
| SCHEMBL24013206 | 0.80 | FCER2 (0.40) | SCN9AFCER2GLO1 | |
| SCHEMBL30493695 | 0.80 | OPRM1 (0.38) | MAPTALDH1A1OPRM1SIRT6SIRT1 | |
| SCHEMBL24899392 | 0.79 | ACE (0.33) | ALDH1A1OPRM1THRBFCER2TLR2 | |
| SCHEMBL18862364 | 0.78 | MAPT (0.53) | MAPTALDH1A1OPRM1SIRT6SIRT1 | |
| SCHEMBL23960483 | 0.77 | — | — | |
| SCHEMBL14008029 | 0.77 | ALDH1A1 (0.55) | MAPTALDH1A1OPRM1SMN1; SMN2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970390-B1 | MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS | BRISTOL MYERS SQUIBB CO (US) | 2019-11-06 | — | — | EP | disclosed |