Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 5/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.37 |
| ▸ | MERTK | Q12866 | 5/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23371374 | 0.78 | NPY5R (0.37) | ADORA3ADORA2AADORA1HTR2BKMT2A | |
| SCHEMBL21554056 | 0.73 | TYRO3 (0.54) | FLT3TYRO3MERTKGAS6SYK | |
| SCHEMBL20873902 | 0.68 | PPARG (0.37) | POLB | |
| SCHEMBL1609288 | 0.68 | NPSR1 (0.40) | ADORA3ADORA2AADORA1KMT2A | |
| SCHEMBL17625052 | 0.66 | KMT2A (0.36) | ADORA3ADORA2AADORA1KMT2A | |
| SCHEMBL13165484 | 0.66 | PDE10A (0.36) | ADORA3ADORA2AADORA1AXLKMT2A | |
| SCHEMBL19822682 | 0.66 | KMT2A (0.36) | ADORA3ADORA2AADORA1AXLKMT2A | |
| SCHEMBL13184884 | 0.66 | PDE4A (0.41) | ADORA3ADORA2AADORA1AXLKMT2A | |
| SCHEMBL20609719 | 0.66 | TYRO3 (0.64) | FLT3TYRO3MERTKGAS6AXL | |
| SCHEMBL16321938 | 0.65 | CYP2C9 (0.38) | ADORA3ADORA2AADORA1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851087-B2 | Synthesis of cerdulatinib | PORTOLA PHARMACEUTICALS, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20190337930-A1 | SYNTHESIS OF CERDULATINIB | ALEXION PHARMACEUTICALS, INC. | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190337930-A1 | SYNTHESIS OF CERDULATINIB | JAK2, DCK, CERS2 | POLB 843/4885ADORA3 3369/4885ADORA2A 3783/4885 |
| US-10851087-B2 | Synthesis of cerdulatinib | JAK2, DCK, CERS2 | POLB 843/4885ADORA3 3369/4885ADORA2A 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.