Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788080 | 0.81 | PDGFRB (0.47) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL21554722 | 0.81 | PDGFRB (0.47) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL21554559 | 0.81 | PDGFRB (0.53) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL21554556 | 0.79 | PDGFRB (0.59) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL19650187 | 0.77 | ALDH1A1 (0.49) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL18768864 | 0.73 | PDGFRB (0.58) | PDGFRBPDGFRACDK2MEN1MAPT | |
| SCHEMBL20306100 | 0.73 | PDGFRB (0.50) | PDGFRBPDGFRACDK2MEN1MAPT | |
| SCHEMBL28180830 | 0.72 | PDE10A (0.52) | PDGFRBPDGFRAALDH1A1HSD17B10HPGD | |
| SCHEMBL16132933 | 0.71 | ALDH1A1 (0.49) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL19650188 | 0.71 | CYP1A2 (0.56) | PDGFRBPDGFRAALDH1A1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776408-B1 | ANTICANCER BENZOPYRAZINES VIA THE INHIBITION OF FGFR KINASES | ASTEX THERAPEUTICS LTD (GB) | 2019-11-06 | — | — | EP | disclosed |