Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21554556 | 0.83 | PDGFRB (0.59) | PDGFRBPDGFRAABCG2ABCB1ABCC1 | |
| SCHEMBL14788080 | 0.81 | PDGFRB (0.47) | PDGFRBPDGFRAABCG2ABCB1ABCC1 | |
| SCHEMBL21554722 | 0.81 | PDGFRB (0.47) | PDGFRBPDGFRAABCG2ABCB1ABCC1 | |
| SCHEMBL21554681 | 0.81 | PDGFRB (0.47) | PDGFRBPDGFRAABCG2ABCB1ABCC1 | |
| SCHEMBL19650188 | 0.77 | CYP1A2 (0.56) | PDGFRBPDGFRAABCG2ABCB1ABCC1 | |
| SCHEMBL10939039 | 0.77 | KDM1A (0.70) | ALDH1A1HPGDHSD17B10CYP3A4KDM1A | |
| SCHEMBL4748569 | 0.73 | LMNA (0.58) | KDM1ANPSR1DOT1LCDK2MAPT | |
| SCHEMBL27890181 | 0.73 | TERT (0.69) | DOT1LMEN1KMT2AALOX15 | |
| SCHEMBL4745308 | 0.73 | NSD2 (0.49) | HSD17B10KDM1ANPSR1DOT1LCDK2 | |
| SCHEMBL29340296 | 0.73 | EGFR (0.50) | PDGFRBPDGFRAABCG2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776408-B1 | ANTICANCER BENZOPYRAZINES VIA THE INHIBITION OF FGFR KINASES | ASTEX THERAPEUTICS LTD (GB) | 2019-11-06 | — | — | EP | disclosed |