Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | DRD4 | P21917 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155468 | 0.92 | GPR119 (0.43) | GPR119L3MBTL1DRD2DRD4CNR2 | |
| SCHEMBL2155345 | 0.76 | GPR119 (0.44) | GPR119L3MBTL1DRD2DRD4CNR2 | |
| SCHEMBL4958144 | 0.76 | GPR119 (0.46) | GPR119L3MBTL1DRD2DRD4CNR2 | |
| SCHEMBL4958147 | 0.74 | GPR119 (0.44) | GPR119L3MBTL1DRD2DRD4CNR2 | |
| SCHEMBL2155271 | 0.74 | GPR119 (0.59) | GPR119L3MBTL1CNR2KMT2AALDH1A1 | |
| SCHEMBL4754484 | 0.73 | GPR119 (0.54) | GPR119L3MBTL1DRD2DRD4CNR2 | |
| SCHEMBL2156464 | 0.72 | LMNA (0.53) | L3MBTL1DRD2DRD4KMT2AGAA | |
| SCHEMBL2155339 | 0.70 | KDM4E (0.44) | GPR119L3MBTL1DRD2DRD4CNR2 | |
| SCHEMBL6927518 | 0.68 | KDM4E (0.55) | DRD2DRD4CNR2PPARGPPARD | |
| SCHEMBL4958636 | 0.68 | GPR119 (0.46) | GPR119L3MBTL1DRD2DRD4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973039-B2 | 3-(1,3-benzodioxol-5-yl)-1-({[4-(4-fluorophenyl)-1-piperazinyl]sulfonyl}methyl)-2-propynyl(hydroxy)formamide; analgesics, anticarcinogenic agents, antiarthritic agents; matrix metalloproteinase inhhibitors | MERCK SERONO SA (CH) | 2011-07-05 | — | — | US | disclosed |