Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2156329 | 0.83 | MMP13 (0.48) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2155666 | 0.82 | KDM4E (0.39) | KDM4ESMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2155607 | 0.81 | HSD17B10 (0.55) | HSD17B10KDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL2154992 | 0.81 | LMNA (0.41) | SMN1; SMN2TSHRMEN1KMT2ALMNA | |
| SCHEMBL2156070 | 0.80 | POLB (0.40) | HSD17B10KDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2155606 | 0.80 | HSD17B10 (0.51) | HSD17B10KDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL16493547 | 0.80 | AR (0.39) | KDM4EALDH1A1POLBLMNA | |
| SCHEMBL2154936 | 0.79 | MAPT (0.33) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2156542 | 0.79 | HSD17B10 (0.52) | HSD17B10KDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL2155377 | 0.79 | LMNA (0.38) | KDM4EALDH1A1THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | claimed |
| US-7973039-B2 | 3-(1,3-benzodioxol-5-yl)-1-({[4-(4-fluorophenyl)-1-piperazinyl]sulfonyl}methyl)-2-propynyl(hydroxy)formamide; analgesics, anticarcinogenic agents, antiarthritic agents; matrix metalloproteinase inhhibitors | MERCK SERONO SA (CH) | 2011-07-05 | — | — | US | claimed |
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | claimed |