Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155666 | 0.90 | KDM4E (0.39) | LMNATP53MAPTSMN1; SMN2GAA | |
| SCHEMBL2155377 | 0.85 | LMNA (0.38) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL5506445 | 0.85 | LMNA (0.35) | LMNATP53MAPT | |
| SCHEMBL2154936 | 0.84 | MAPT (0.33) | MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2156070 | 0.83 | POLB (0.40) | LMNAMAPTSMN1; SMN2TSHRMEN1 | |
| SCHEMBL2154831 | 0.83 | MMP7 (0.36) | MAPTKMT2A | |
| SCHEMBL2156227 | 0.82 | LMNA (0.43) | LMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL2156329 | 0.82 | MMP13 (0.48) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL2155603 | 0.81 | HSD17B10 (0.51) | LMNASMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL16493547 | 0.81 | AR (0.39) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | claimed |
| US-7973039-B2 | 3-(1,3-benzodioxol-5-yl)-1-({[4-(4-fluorophenyl)-1-piperazinyl]sulfonyl}methyl)-2-propynyl(hydroxy)formamide; analgesics, anticarcinogenic agents, antiarthritic agents; matrix metalloproteinase inhhibitors | MERCK SERONO SA (CH) | 2011-07-05 | — | — | US | claimed |