Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632895 | 0.87 | ALDH1A1 (0.39) | ALDH1A1HSD17B10TDP1FFAR4PTPRZ1 | |
| SCHEMBL65853 | 0.84 | FFAR4 (0.49) | ALDH1A1HSD17B10TDP1FFAR4BCHE | |
| Ammonia Solution, Strong SCHEMBL26923048 | 0.82 | FFAR4 (0.47) | ALDH1A1HSD17B10TDP1FFAR4BCHE | |
| SCHEMBL20474626 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TDP1PTGS2PTGS1KIF11 | |
| SCHEMBL3310741 | 0.79 | MMP9 (0.54) | ALDH1A1FFAR4BCHEACHEMMP2 | |
| SCHEMBL1489401 | 0.79 | TRPV1 (0.40) | ALDH1A1HSD17B10TDP1FFAR4PTPRZ1 | |
| SCHEMBL9778890 | 0.79 | HTT (0.47) | ALDH1A1HSD17B10TDP1HSD11B1MMP2 | |
| SCHEMBL11683700 | 0.78 | ALDH1A1 (0.38) | ALDH1A1HSD17B10TDP1FFAR4PTPRZ1 | |
| SCHEMBL4323508 | 0.76 | ALDH1A1 (0.43) | ALDH1A1HSD17B10TDP1FFAR4PTGS2 | |
| SCHEMBL28829759 | 0.75 | ALDH1A1 (0.35) | ALDH1A1HSD17B10TDP1FFAR4PTPRZ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472386-B2 | Bile acid derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472386-B2 | Bile acid derivatives as FXR agonists and methods of use thereof | NR1H4, GPBAR1, SLC10A1 | ALDH1A1 1993/4885HSD17B10 198/4885TDP1 2842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.