Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.35 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.35 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.35 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.35 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.35 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.35 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.35 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.35 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.35 |
| ▸ | PSMA8 | Q8TAA3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21558030 | 0.80 | EGFR (0.39) | EGFRFGFR4TGM2 | |
| SCHEMBL28579321 | 0.78 | MAPT (0.47) | EGFRFGFR4PSMB11PSMA7PSMB1 | |
| SCHEMBL24429190 | 0.77 | TGM2 (0.41) | FGFR4PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL15345353 | 0.76 | TGM2 (0.44) | EGFRPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL21557748 | 0.75 | TGM2 (0.41) | EGFRFGFR4PSMB11PSMA7PSMB1 | |
| SCHEMBL15345350 | 0.73 | TGM2 (0.42) | FGFR4PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL17196860 | 0.73 | EGFR (0.51) | EGFR | |
| SCHEMBL19732109 | 0.71 | EGFR (0.40) | EGFRFGFR4BTKGAKFGFR1 | |
| SCHEMBL17059206 | 0.70 | EGFR (0.57) | EGFR | |
| SCHEMBL19221937 | 0.70 | EGFR (0.49) | EGFRFGFR4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844642-B1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMA INC (US) | 2019-11-13 | — | — | EP | disclosed |