Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | TGM1 | P22735 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21558029 | 0.80 | EGFR (0.37) | EGFRTGM2FGFR4 | |
| SCHEMBL15600880 | 0.72 | EGFR (0.65) | EGFRMAPK3 | |
| SCHEMBL28579321 | 0.70 | MAPT (0.47) | EGFRTGM2FGFR4MAPK3 | |
| SCHEMBL30344144 | 0.69 | KDM4E (0.33) | AAK1HTR4 | |
| SCHEMBL25155888 | 0.69 | KDM4E (0.33) | AAK1HTR4 | |
| SCHEMBL15345353 | 0.68 | TGM2 (0.44) | EGFRTGM2MAPK3 | |
| SCHEMBL21557748 | 0.67 | TGM2 (0.41) | EGFRTGM2FGFR4MAPK3 | |
| SCHEMBL24429190 | 0.67 | TGM2 (0.41) | TGM2FGFR4MAPK3 | |
| SCHEMBL17059206 | 0.67 | EGFR (0.57) | EGFR | |
| SCHEMBL19221937 | 0.67 | EGFR (0.49) | EGFRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844642-B1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMA INC (US) | 2019-11-13 | — | — | EP | disclosed |