Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.38 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.38 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28579321 | 0.87 | MAPT (0.47) | TGM2EGFRERBB3DUS2FGFR4 | |
| SCHEMBL15345353 | 0.84 | TGM2 (0.44) | TGM2EGFRERBB3DUS2MAPK3 | |
| SCHEMBL24429190 | 0.83 | TGM2 (0.41) | TGM2FGFR4FGFR1MAPK3FGFR2 | |
| SCHEMBL14225885 | 0.82 | CA1 (0.44) | MEN1MAPTHTTKMT2A | |
| SCHEMBL15345350 | 0.81 | TGM2 (0.42) | TGM2FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL19732109 | 0.77 | EGFR (0.40) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL19221937 | 0.75 | EGFR (0.49) | EGFRFGFR4FGFR1KDR | |
| SCHEMBL19089377 | 0.75 | BRPF1 (0.47) | EGFRFGFR1 | |
| SCHEMBL21558029 | 0.75 | EGFR (0.37) | TGM2EGFRFGFR4FGFR1FGFR2 | |
| SCHEMBL31348830 | 0.75 | EGFR (0.53) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844642-B1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMA INC (US) | 2019-11-13 | — | — | EP | disclosed |