Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21290242 | 0.82 | TDP1 (0.49) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL21559738 | 0.80 | KDM4E (0.44) | TDP1KMT2ALMNACYP3A4KDM4E | |
| SCHEMBL24510712 | 0.77 | ALDH1A1 (0.47) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL24070239 | 0.77 | TDP1 (0.46) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL21350549 | 0.75 | ALDH1A1 (0.52) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL21923219 | 0.74 | KMT2A (0.43) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL25698449 | 0.73 | KMT2A (0.43) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL13733547 | 0.73 | TDP1 (0.47) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL20651056 | 0.72 | TDP1 (0.46) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL22946291 | 0.72 | TDP1 (0.61) | TDP1KMT2ASLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067629-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2024-02-29 | — | — | US | disclosed |
| US-11753399-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11267801-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2022-03-08 | — | — | US | disclosed |
| US-20210171498-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2021-06-10 | — | — | US | disclosed |
| US-10836746-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2020-11-17 | — | — | US | disclosed |
| US-20190345136-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267801-B2 | Therapeutic compounds | NPC1, CCR5, FURIN | TDP1 4124/4885KMT2A 3635/4885SLC6A2 129/4885 |
| US-20240067629-A1 | THERAPEUTIC COMPOUNDS | NPC1, CCR5, FURIN | TDP1 4124/4885KMT2A 3635/4885SLC6A2 129/4885 |
| US-20210171498-A1 | THERAPEUTIC COMPOUNDS | NPC1, CCR5, FURIN | TDP1 4124/4885KMT2A 3635/4885SLC6A2 129/4885 |
| US-10836746-B2 | Therapeutic compounds | NPC1, CCR5, FURIN | TDP1 4124/4885KMT2A 3635/4885SLC6A2 129/4885 |
| US-20190345136-A1 | THERAPEUTIC COMPOUNDS | NPC1, CCR5, FURIN | TDP1 4124/4885KMT2A 3635/4885SLC6A2 129/4885 |
| US-11753399-B2 | Therapeutic compounds | NPC1, CCR5, FURIN | TDP1 4124/4885KMT2A 3635/4885SLC6A2 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.