Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333919 | 0.83 | ALDH1A1 (0.43) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL7882044 | 0.82 | JMJD6 (0.52) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL4857159 | 0.80 | L3MBTL1 (0.50) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL21559637 | 0.77 | TDP1 (0.45) | TDP1KMT2ASLC6A2SLC6A3L3MBTL1 | |
| SCHEMBL9207547 | 0.77 | KCNA5 (0.48) | L3MBTL1POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL25893352 | 0.77 | TDP1 (0.47) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL20651056 | 0.76 | TDP1 (0.46) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL28740303 | 0.75 | JMJD6 (0.44) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL2152994 | 0.75 | L3MBTL1 (0.49) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL28714507 | 0.75 | GABRA1 (0.58) | TDP1TSHRRAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3967682-A1 | BISHETEROCYCLIC CARBONYL SUBSTITUTED DIHYDROPYRAZOLE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2022-03-16 | — | — | EP | disclosed |
| WO-2021239058-A1 | FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2021-12-02 | — | — | WO | disclosed |