Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 14/20 | 0.72 |
| ▸ | SHMT2 | P34897 | 12/20 | 0.71 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21560027 | 1.00 | SHMT1 (0.72) | SHMT1SHMT2EGLN1PTGER1PRKD3 | |
| SCHEMBL21560101 | 1.00 | SHMT1 (0.72) | SHMT1SHMT2EGLN1PTGER1PRKD3 | |
| SCHEMBL20255630 | 0.89 | EGLN1 (0.57) | SHMT1SHMT2EGLN1 | |
| SCHEMBL21560158 | 0.89 | EGLN1 (0.57) | SHMT1SHMT2EGLN1 | |
| SCHEMBL20255635 | 0.89 | EGLN1 (0.57) | SHMT1SHMT2EGLN1 | |
| SCHEMBL21560349 | 0.88 | SHMT1 (0.59) | SHMT1SHMT2EGLN1PTGER1 | |
| SCHEMBL20255684 | 0.87 | SHMT1 (0.66) | SHMT1SHMT2EGLN1 | |
| SCHEMBL20255548 | 0.86 | EGLN1 (0.57) | SHMT1SHMT2EGLN1TLR7 | |
| SCHEMBL20255544 | 0.86 | EGLN1 (0.57) | SHMT1SHMT2EGLN1TLR7 | |
| SCHEMBL20255638 | 0.86 | EGLN1 (0.57) | SHMT1SHMT2EGLN1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091451-B2 | SHMT inhibitors and uses thereof | RAZE THERAPEUTICS, INC. (US) | 2021-08-17 | — | — | US | disclosed |
| US-20190345119-A1 | SHMT INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091451-B2 | SHMT inhibitors and uses thereof | SHMT1, SHMT2, BHMT | SHMT1 1/4885SHMT2 2/4885EGLN1 250/4885 |
| US-20190345119-A1 | SHMT INHIBITORS AND USES THEREOF | SHMT1, SHMT2, BHMT | SHMT1 1/4885SHMT2 2/4885EGLN1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.