Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155684 | 0.71 | ACHE (0.40) | MAPTTDP1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2156050 | 0.69 | MAPT (0.38) | MAPTTDP1ALDH1A1LMNAACHE | |
| SCHEMBL23181246 | 0.64 | MAPT (0.48) | MAPTTDP1ALDH1A1LMNAACHE | |
| SCHEMBL8787780 | 0.64 | MAPT (0.48) | MAPTTDP1ALDH1A1LMNAACHE | |
| SCHEMBL2155997 | 0.63 | MAPT (0.44) | MAPTTDP1ALDH1A1LMNAACHE | |
| SCHEMBL10381710 | 0.63 | LMNA (0.44) | MAPTTDP1ALDH1A1LMNAACHE | |
| SCHEMBL18176287 | 0.62 | ALDH1A1 (0.56) | MAPTTDP1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2601428 | 0.62 | ALDH1A1 (0.49) | MAPTTDP1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL900830 | 0.62 | ALDH1A1 (0.68) | MAPTTDP1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11602789 | 0.62 | ALDH1A1 (0.62) | MAPTTDP1ALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973072-B2 | Pain, eating disorders, neurodegenerative disorders, memory impairment; attention deficit syndrome, opioid tolerance, drug addiction; (4-oxothiochroman-3,3-diyl)bis(methylene)bis(3-(trifluoromethyl)benzoate for example | GRUENENTHAL GMBH (DE) | 2011-07-05 | — | — | US | claimed |