Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15061709 | 0.82 | HPGD (0.50) | HPGDHSD17B10SMN1; SMN2MAPTTSHR | |
| SCHEMBL15850486 | 0.81 | ALDH1A1 (0.33) | MAPTTSHRALDH1A1 | |
| SCHEMBL787343 | 0.80 | — | — | |
| SCHEMBL19137249 | 0.80 | HPGD (0.42) | HPGDHSD17B10SMN1; SMN2MAPTTSHR | |
| SCHEMBL2308779 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL27749339 | 0.78 | HPGD (0.46) | HPGDHSD17B10SMN1; SMN2MAPTTSHR | |
| SCHEMBL25683301 | 0.77 | SMN1; SMN2 (0.41) | HPGDHSD17B10SMN1; SMN2MAPTTSHR | |
| SCHEMBL13714091 | 0.77 | MAPT (0.48) | HPGDHSD17B10SMN1; SMN2MAPTTSHR | |
| SCHEMBL19198544 | 0.77 | — | — | |
| SCHEMBL13470295 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019215203-A1 | TETRACYCLIC HETEROARYL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-11-14 | — | — | WO | disclosed |