Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21564575 | 0.90 | HRH4 (0.40) | NOS3NOS1NOS2HRH4 | |
| SCHEMBL21564583 | 0.89 | RAF1 (0.37) | — | |
| SCHEMBL21564662 | 0.87 | NOS3 (0.31) | NOS3NOS1NOS2 | |
| SCHEMBL26032668 | 0.80 | HRH3 (0.36) | HRH4 | |
| SCHEMBL23258796 | 0.79 | KDM4E (0.38) | KDM4E | |
| SCHEMBL21564596 | 0.78 | MAPT (0.35) | KDM4E | |
| SCHEMBL21564756 | 0.78 | MAPT (0.35) | KDM4E | |
| SCHEMBL21552972 | 0.76 | DUT (0.38) | — | |
| SCHEMBL21552819 | 0.74 | HRH4 (0.41) | HRH4KDM4E | |
| SCHEMBL21564457 | 0.74 | HRH4 (0.41) | NOS3NOS1NOS2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217972-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. (US) | 2019-11-14 | — | — | WO | disclosed |