Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 3/20 | 0.35 |
| ▸ | STK3 | Q13188 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21564765 | 0.89 | NOS3 (0.34) | — | |
| SCHEMBL21564575 | 0.86 | HRH4 (0.40) | TSHR | |
| SCHEMBL21564662 | 0.83 | NOS3 (0.31) | — | |
| SCHEMBL21564770 | 0.79 | LMNA (0.41) | RAF1BRAFLMNAMAPTKMT2A | |
| SCHEMBL23258796 | 0.76 | KDM4E (0.38) | LMNAMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL21553051 | 0.76 | KDM1A (0.44) | STK4STK3LRRK2 | |
| SCHEMBL23258177 | 0.73 | ALDH1A1 (0.49) | RAF1BRAFLMNAMAPTKMT2A | |
| SCHEMBL26032668 | 0.72 | HRH3 (0.36) | PDE4BLMNAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL28714095 | 0.72 | NOS3 (0.47) | LMNAMAPTKMT2AMEN1 | |
| SCHEMBL21564457 | 0.71 | HRH4 (0.41) | ZAP70SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217972-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. (US) | 2019-11-14 | — | — | WO | disclosed |