Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568161 | 0.89 | KDM4E (0.57) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL26034949 | 0.86 | DYRK1A (0.61) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL21568324 | 0.83 | DYRK1A (0.58) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL21568130 | 0.82 | DYRK1A (0.65) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL23256895 | 0.82 | DYRK1A (0.68) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL21568083 | 0.82 | KDM4E (0.56) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL27093077 | 0.81 | DYRK1A (0.67) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL21568266 | 0.80 | NPC1 (0.56) | DYRK1AMEN1KMT2AMAPTPOLB | |
| SCHEMBL21569108 | 0.80 | KDM4E (0.56) | DYRK1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL4124786 | 0.80 | DYRK1A (0.74) | DYRK1AMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019217509-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | HB THERAPEUTICS INC. (US) | 2019-11-14 | — | — | WO | disclosed |