Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25149135 | 0.82 | PLAU (0.43) | PLAUS1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL26664362 | 0.82 | PLAU (0.38) | PLAU | |
| SCHEMBL31200216 | 0.82 | PLAU (0.38) | PLAU | |
| SCHEMBL30450119 | 0.82 | PLAU (0.38) | PLAU | |
| SCHEMBL19761076 | 0.82 | PLAU (0.38) | PLAU | |
| SCHEMBL31200071 | 0.80 | PLAU (0.36) | PLAUSMN1; SMN2 | |
| SCHEMBL28535951 | 0.75 | PLAU (0.41) | PLAUS1PR1S1PR3 | |
| SCHEMBL18128809 | 0.73 | MEN1 (0.34) | PLAU | |
| SCHEMBL16795113 | 0.73 | MEN1 (0.34) | PLAU | |
| SCHEMBL12267661 | 0.71 | L3MBTL1 (0.38) | PLAUS1PR1S1PR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230255941-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2023-08-17 | — | — | US | disclosed |
| US-11672780-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-13 | — | — | US | disclosed |
| US-20210085651-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2021-03-25 | — | — | US | disclosed |
| US-10478424-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210085651-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, TLR5 | PLAU 3516/4885S1PR1 233/4885S1PR3 389/4885 |
| US-11672780-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | TLR7, TLR1, TLR5 | PLAU 3516/4885S1PR1 233/4885S1PR3 389/4885 |
| US-10478424-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | TLR7, TLR1, TLR5 | PLAU 3516/4885S1PR1 233/4885S1PR3 389/4885 |
| US-20230255941-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, TLR5 | PLAU 3516/4885S1PR1 233/4885S1PR3 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.