Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21572805 | 0.88 | ALDH1A1 (0.48) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL20583508 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL20583510 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL21572798 | 0.83 | ALDH1A1 (0.52) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL12302913 | 0.81 | BACE1 (0.58) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL20583297 | 0.81 | ALDH1A1 (0.47) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL20583295 | 0.81 | ALDH1A1 (0.47) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL18970304 | 0.81 | ABCC4 (0.55) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL18970284 | 0.81 | ABCC4 (0.55) | ALDH1A1LMNAKMT2AMEN1MME | |
| SCHEMBL22295411 | 0.80 | LMNA (0.53) | ALDH1A1LMNAKMT2AMEN1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD (CN) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | DPP4, ACE, DPP8 | ALDH1A1 308/4885LMNA 1222/4885KMT2A 2323/4885 |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | ACE, DPP4, SI | ALDH1A1 339/4885LMNA 2313/4885KMT2A 2412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.