Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.60 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.60 |
| ▸ | DNPH1 | O43598 | 3/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.58 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.58 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.58 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216009 | 0.94 | P2RX3 (0.60) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL216645 | 0.92 | P2RX3 (0.70) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL4820076 | 0.91 | P2RX3 (0.71) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL25698378 | 0.88 | P2RX3 (0.72) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL20705924 | 0.88 | P2RX3 (0.72) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL4217929 | 0.85 | P2RX3 (0.82) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL8738522 | 0.85 | P2RX3 (0.82) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL30853828 | 0.85 | P2RX3 (0.82) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL4820592 | 0.85 | DNPH1 (0.73) | P2RX3P2RX2DNPH1TAS1R3TAS1R1 | |
| SCHEMBL2104470 | 0.85 | DNPH1 (0.63) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088897-B2 | Detecting the activity of and screening acceptor substrates, inhibitors, or activators of enzymes catalyzing group transfer reactions to facilitate the development of more selective and therapeutic drugs | BellBrook Labs, Inc. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20080233592-A1 | Assay Method for Group Transfer Reactions | BELLBROOK LABS, LLC | 2008-09-25 | — | — | US | disclosed |
| US-7378505-B2 | Assay method for group transfer reactions | BELLBROOK LABS LLC (US) | 2008-05-27 | — | — | US | disclosed |
| US-20060172335-A1 | Assay method for group transfer reactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-08-03 | — | — | US | disclosed |