Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | ELANE | P08246 | 8/20 | 0.48 |
| ▸ | S100A4 | P26447 | 4/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17278322 | 1.00 | EGFR (0.52) | EGFRPIM1MEN1KMT2AELANE | |
| SCHEMBL567474 | 0.86 | EGFR (0.54) | EGFRPIM1MEN1KMT2AELANE | |
| SCHEMBL14537729 | 0.86 | EGFR (0.54) | EGFRPIM1MEN1KMT2AELANE | |
| Hydrochloric Acid SCHEMBL29658548 | 0.85 | EGFR (0.53) | EGFRPIM1MEN1KMT2AELANE | |
| Hydrochloric Acid SCHEMBL7460 | 0.85 | EGFR (0.53) | EGFRPIM1MEN1KMT2AELANE | |
| SCHEMBL13452107 | 0.85 | EGFR (0.53) | EGFRPIM1MEN1KMT2AELANE | |
| SCHEMBL13472029 | 0.84 | MAOA (0.49) | MEN1KMT2AELANECTSGCYP3A4 | |
| SCHEMBL22873368 | 0.83 | EGFR (0.51) | EGFRPIM1MEN1KMT2AELANE | |
| SCHEMBL21886965 | 0.83 | EGFR (0.51) | EGFRPIM1MEN1KMT2AELANE | |
| SCHEMBL11395596 | 0.83 | EGFR (0.51) | EGFRPIM1MEN1KMT2AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3693391-A1 | ANTI-CLL-1 ANTIBODIES AND IMMUNOCONJUGATES | Genentech, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3191134-B1 | ANTHRACYCLINE DISULFIDE INTERMEDIATES, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH INC (US) | 2019-11-20 | — | — | EP | disclosed |