Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099038 | 0.80 | HRH4 (0.37) | — | |
| SCHEMBL19764588 | 0.80 | HRH4 (0.37) | — | |
| SCHEMBL5276540 | 0.78 | HCAR2 (0.40) | KDM4E | |
| SCHEMBL9750315 | 0.76 | HCAR2 (0.36) | — | |
| SCHEMBL27562862 | 0.71 | — | — | |
| SCHEMBL17942070 | 0.70 | MAPT (0.33) | — | |
| SCHEMBL23284266 | 0.64 | — | — | |
| SCHEMBL17084633 | 0.63 | L3MBTL1 (0.65) | KDM4EMAPK1POLB | |
| SCHEMBL29221863 | 0.63 | NOS3 (0.35) | KDM4EMAPK1NOS3NOS1NOS2 | |
| SCHEMBL5278803 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3247705-B1 | QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF AS NAMPT INHIBITORS | MILLENNIUM PHARM INC (US) | 2019-11-20 | — | — | EP | disclosed |