Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.45 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632856 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NOTUMMAPT | |
| SCHEMBL16632854 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NOTUMMAPT | |
| SCHEMBL6851730 | 0.75 | KDM4E (0.58) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL6876917 | 0.75 | KDM4E (0.58) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL6852339 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL6852332 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL6852346 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL13221930 | 0.72 | ALDH1A1 (0.68) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL10653293 | 0.71 | KDM4E (0.72) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 | |
| SCHEMBL11410050 | 0.71 | KDM4E (0.72) | KDM4EALDH1A1MAPK1CHRNA7CHRNA10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |