Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214569 | 0.82 | ALDH1A1 (0.47) | HCAR1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL13481029 | 0.78 | FGFR1 (0.50) | HCAR1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL18268477 | 0.76 | LMNA (0.50) | PI4KAPI4K2BPI4K2API4KBHCAR1 | |
| SCHEMBL28141593 | 0.75 | PI4KA (0.50) | PI4KAPI4K2BPI4K2API4KBHCAR1 | |
| SCHEMBL213390 | 0.74 | POLB (0.45) | ALDH1A1TSHRKDM4EADORA2AKAT2B | |
| SCHEMBL29829372 | 0.72 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBHCAR1 | |
| SCHEMBL9714613 | 0.72 | CYP11B1 (0.50) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL22732231 | 0.71 | HSP90AA1 (0.44) | PI4KAPI4K2BPI4K2API4KBHCAR1 | |
| SCHEMBL27954108 | 0.71 | MAPT (0.41) | PI4KAPI4K2BPI4K2API4KBHCAR1 | |
| SCHEMBL18268462 | 0.71 | TP53 (0.51) | PI4KAPI4K2BPI4K2API4KBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |