Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215765 | 0.82 | PI4KA (0.43) | ALDH1A1HCAR1MEN1KMT2AHSD17B10 | |
| SCHEMBL213975 | 0.76 | KMT2A (0.42) | ALDH1A1MEN1KMT2AHSD17B10GAA | |
| SCHEMBL213700 | 0.74 | SORT1 (0.46) | ALDH1A1MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL215824 | 0.71 | RAB9A (0.41) | ALDH1A1MEN1KMT2AGAAPOLB | |
| SCHEMBL213156 | 0.71 | LMNA (0.46) | ALDH1A1MEN1KMT2AGAAHPGD | |
| SCHEMBL217145 | 0.71 | SMN1; SMN2 (0.39) | HCAR1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL215228 | 0.70 | SCN9A (0.44) | ALDH1A1MEN1KMT2AGAAPOLB | |
| SCHEMBL215860 | 0.70 | MEN1 (0.38) | ALDH1A1MEN1KMT2AGAAPOLB | |
| SCHEMBL13481029 | 0.69 | FGFR1 (0.50) | ALDH1A1HCAR1MEN1KMT2AHSD17B10 | |
| SCHEMBL214745 | 0.69 | KMT2A (0.41) | ALDH1A1MEN1KMT2AHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |