Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 6/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAP2 | P11137 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214571 | 0.82 | SLC9A1 (0.56) | SLC9A1IKBKBALDH1A1HPGDJAK2 | |
| SCHEMBL10694398 | 0.80 | SLC9A1 (0.54) | SLC9A1IKBKBNPC1ALDH1A1HPGD | |
| SCHEMBL3418406 | 0.75 | TEK (0.50) | SLC9A1ALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL8963998 | 0.75 | SLC9A1 (0.66) | SLC9A1IKBKBNPC1ALDH1A1HPGD | |
| SCHEMBL213392 | 0.73 | METAP2 (0.46) | NPC1ALDH1A1HPGDHTTRAB9A | |
| SCHEMBL29411925 | 0.71 | PARP1 (0.72) | — | |
| SCHEMBL216640 | 0.71 | SLC9A1 (0.36) | SLC9A1PIN1 | |
| SCHEMBL8963633 | 0.71 | SLC9A1 (0.60) | SLC9A1NPC1ALDH1A1HPGDHTT | |
| SCHEMBL8963796 | 0.71 | SLC9A1 (0.50) | SLC9A1IKBKBNPC1ALDH1A1HPGD | |
| SCHEMBL4787187 | 0.69 | SLC9A1 (0.53) | SLC9A1IKBKBNPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |