SCHEMBL21577555

SCHEMBL21577555

Cc1cc(C)c(C)c(-c2ccc3ccc(CC(C)C)cc3n2)c1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 0.37
KDM4E B2RXH2 1/20 0.34
DHODH Q02127 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
XDH P47989 1/20 0.31
NR3C1 P04150 1/20 0.30
PGR P06401 1/20 0.30
NR3C2 P08235 1/20 0.30
ABL1 P00519 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22520245 0.82 AR (0.38) ARNOS3NOS1NOS2
SCHEMBL4436058 0.80 DHODH (0.39) KDM4EDHODHGABRA1GABRB2NOS3
SCHEMBL13989407 0.79 CYP1A2 (0.48) ARKDM4E
SCHEMBL19258033 0.79 ABL1 (0.38) KDM4EGABRA1GABRB2NOS3NOS1
SCHEMBL26300010 0.79 KDM4E (0.33) KDM4E
SCHEMBL16424865 0.76 AR (0.38) ARDHODHGABRA1GABRB2NR3C1
SCHEMBL21168713 0.75 DHODH (0.52) KDM4EDHODH
SCHEMBL16310381 0.75 AR (0.59) ARKDM4E
SCHEMBL20809319 0.74 CTSS (0.40) KDM4EDHODHXDH
SCHEMBL18508278 0.74 CTSS (0.36) KDM4EDHODHNOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190355912-A1 ORGANIC ELECTROLUMINESCENT DEVICE ROHM & HAAS ELECT MATERIALS KOREA LTD (KR) 2019-11-21 US disclosed