SCHEMBL21579656

SCHEMBL21579656

Cn1c(N)nc2c(=O)[nH]cnc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.45
HPRT1 P00492 6/20 0.43
ATAD2 Q6PL18 1/20 0.42
PIK3CD O00329 1/20 0.41
ALPL P05186 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
TMIGD3 P0DMS9 1/20 0.41
PDE4A P27815 1/20 0.41
ADORA2A P29274 1/20 0.41
ADORA2B P29275 1/20 0.41
ADORA1 P30542 1/20 0.41
CYP2C19 P33261 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
HIF1A Q16665 1/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
MAPT P10636 1/20 0.41
PNP P00491 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14441125 0.82 ALDH1A1 (0.45) ALDH1A1HPRT1ATAD2PIK3CDALPL
SCHEMBL23867066 0.81 ALDH1A1 (0.44) ALDH1A1HPRT1ATAD2PIK3CDALPL
SCHEMBL13202761 0.81 ADORA2A (0.51) ALDH1A1HPRT1ATAD2PIK3CDALPL
SCHEMBL21273219 0.77 PARP1 (0.41) ALDH1A1HPRT1ATAD2PIK3CDALPL
SCHEMBL1992701 0.76 HPRT1 (0.54) ALDH1A1HPRT1ADORA2AADORA1PNP
SCHEMBL48434 0.75 ATAD2 (0.54) ATAD2PIK3CDALPLADORA3TMIGD3
SCHEMBL21393362 0.74 POLB (0.43) ALDH1A1ATAD2PIK3CDALPLADORA3
SCHEMBL12820649 0.73 PNP (0.57) ALDH1A1MAPTPNP
SCHEMBL5429656 0.72 MEN1 (0.51) ALDH1A1ADORA3ADORA2AADORA2BADORA1
SCHEMBL5429613 0.70 ADORA2A (0.41) ALDH1A1ADORA3ADORA2AADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037636-B2 Polynucleotide synthesis method, kit and system OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-07-16 US disclosed
US-12037636-B2 Polynucleotide synthesis method, kit and system OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-07-16 US disclosed
US-20220396818-A1 POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2022-12-15 US disclosed
US-20220213537-A1 POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2022-07-07 US disclosed
US-20220177938-A1 POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2022-06-09 US disclosed
US-20220177937-A1 POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2022-06-09 US disclosed
US-20210388432-A1 POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2021-12-16 US disclosed
US-20210324436-A1 METHODS AND REAGENTS FOR SYNTHESISING POLYNUCLEOTIDE MOLECULES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2021-10-21 US disclosed
US-20210198710-A1 POLYNUCLEOTIDE SYNTHESIS METHOD, SYSTEM AND KIT OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2021-07-01 US disclosed
US-10927394-B2 Methods and reagents for synthesising polynucleotide molecules OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2021-02-23 US disclosed
US-20190352687-A1 METHODS AND REAGENTS FOR SYNTHESISING POLYNUCLEOTIDE MOLECULES OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2019-11-21 US disclosed