Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 16/20 | 0.57 |
| ▸ | CASP7 | P55210 | 11/20 | 0.57 |
| ▸ | CASP1 | P29466 | 7/20 | 0.57 |
| ▸ | CASP9 | P55211 | 7/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.51 |
| ▸ | CASP4 | P49662 | 3/20 | 0.46 |
| ▸ | CASP10 | Q92851 | 3/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.45 |
| ▸ | CASP5 | P51878 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370165 | 0.90 | CASP3 (0.46) | CASP3CASP7CASP1CASP9PTGER4 | |
| SCHEMBL14968961 | 0.89 | PTGER4 (0.51) | PTGER4 | |
| SCHEMBL2168561 | 0.88 | CASP3 (0.41) | CASP3CASP7CASP1CASP9PTGER4 | |
| SCHEMBL4321426 | 0.87 | BACE1 (0.44) | CASP3CASP7CASP1CASP9PTGER4 | |
| SCHEMBL29362585 | 0.80 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP4 | |
| SCHEMBL17326941 | 0.80 | CASP3 (0.72) | CASP3CASP7CASP1CASP9CASP4 | |
| SCHEMBL7358758 | 0.79 | PTGER4 (0.58) | PTGER4 | |
| SCHEMBL4413420 | 0.79 | PTGER4 (0.58) | PTGER4 | |
| SCHEMBL6024083 | 0.79 | MAGI3 (0.42) | PTGER4 | |
| SCHEMBL20239336 | 0.79 | CASP3 (0.71) | CASP3CASP7CASP1CASP9CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183358-A1 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | THE BURNHAM INSTITUTE (US) | 2011-07-28 | — | — | US | disclosed |
| US-20090098577-A1 | METHOD OF IDENTIFYING COMPOUNDS THAT MODULATE CASPASE 9 ACTIVITY VIA USE OF A KOSMOTROPIC SALT | WYETH (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090043099-A1 | Methods and compositions for derepression of IAP-inhibited caspase | THE BURNHAM INSTITUTE (US) | 2009-02-12 | — | — | US | disclosed |
| US-7452683-B2 | Identifying enzyme modulators for treating neurodegenerative, autoimmune and tumor diseases | WYETH (US) | 2008-11-18 | — | — | US | disclosed |
| EP-1951278-A2 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | The Burnham Institute (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1865977-A2 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | The Burnham Institute for Medical Research (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20070271634-A1 | Preventing stress-induced apoptosis in plants | DICKMAN MARTIN B | 2007-11-22 | — | — | US | disclosed |
| US-7217688-B2 | Methods and compositions for derepression of IAP-inhibited caspase | THE BURNHAM INSTITUTE (US) | 2007-05-15 | — | — | US | disclosed |
| WO-2007047551-A2 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | THE BURNHAM INSTITUTE (US) | 2007-04-26 | — | — | WO | disclosed |
| US-20070003535-A1 | Methods and compositions for derepression of IAP-inhibited caspase | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-01-04 | — | — | US | disclosed |
| EP-1161556-A2 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | Idun Pharmaceuticals, Inc. (US) | 2001-12-12 | — | — | EP | disclosed |
| US-20010016345-A1 | Apoptotic protease Mch6, nucleic acids encoding same and methods of use | ALNEMRI EMAD S (US) | 2001-08-23 | — | — | US | disclosed |
| US-6274318-B1 | DETECTING MODULATORS OF ENZYME ACTIVITY; INCUBATE ENZYMATIC SAMPLE AND INHIBITOR, DETECT REDUCE ACTIVITY FROM ENZYME | THOMAS JEFFERSON UNIVERSITY | 2001-08-14 | — | — | US | disclosed |
| US-6270980-B1 | DETECTING MODULATORS OF CELL KILLING ACTIVITY; INCUBATE CELLS AND DIAGNOSTIC REAGENT, MONITOR INDUCED KILLING ACTIVITY IN CELLS | IDUN PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | disclosed |
| US-20010006779-A1 | APOPTOTIC PROTEASE MCH6, NUCLEIC ACIDS ENCODING SAME AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH, THE | 2001-07-05 | — | — | US | disclosed |
| US-6251614-B1 | DETECTING MODULATORS OF APOPTOSIS; INCUBATE CELLS WITH MODULATORS AND MEASURE APOPTOTIC ACTIVITY IN CELLS | IDUN PHARMACEUTICALS, INC. | 2001-06-26 | — | — | US | disclosed |
| WO-2000052194-A2 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | IDUN PHARMACEUTICALS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000026391-A2 | TRANS-SPECIES TRANSFER OF APOPTOTIC GENES AND TRANSGENIC PLANTS DEVELOPED THEREBY | UNIVERSITY OF NEBRASKA-LINCOLN (US) | 2000-05-11 | — | — | WO | disclosed |
| EP-0988545-A1 | RAPID METHODS FOR IDENTIFYING MODIFIERS OF CELLULAR APOPTOSIS ACTIVITY | Idun Pharmaceuticals, Inc. (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998055863-A1 | RAPID METHODS FOR IDENTIFYING MODIFIERS OF CELLULAR APOPTOSIS ACTIVITY | IDUN PHARMACEUTICALS, INC. (US) | 1998-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070003535-A1 | Methods and compositions for derepression of IAP-inhibited caspase | BIRC5, API5, BIRC3 | CASP3 12/4885CASP7 11/4885CASP1 10/4885 |
| US-20090043099-A1 | Methods and compositions for derepression of IAP-inhibited caspase | BIRC5, API5, BIRC3 | CASP3 12/4885CASP7 11/4885CASP1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.