Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 10/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.38 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.38 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321426 | 0.92 | BACE1 (0.44) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL2157993 | 0.88 | CASP3 (0.57) | CASP3CASP1CASP7CASP9PTGER4 | |
| SCHEMBL6024083 | 0.88 | MAGI3 (0.42) | BACE1MMP2MMP9ADAM17PTGER4 | |
| SCHEMBL3366840 | 0.85 | CASP1 (0.51) | CASP3CASP1CASP7BACE1BACE2 | |
| SCHEMBL4264976 | 0.80 | OPRD1 (0.55) | BACE1BACE2 | |
| SCHEMBL3370165 | 0.79 | CASP3 (0.46) | CASP3CASP1CASP7CASP9PTGER4 | |
| SCHEMBL5614017 | 0.78 | MAOB (0.41) | CASP3BACE1MMP2MMP9ADAM17 | |
| SCHEMBL2157759 | 0.78 | OPRD1 (0.52) | BACE1BACE2 | |
| SCHEMBL7220733 | 0.78 | TSHR (0.49) | CASP1CASP7MMP2MMP9ADAM17 | |
| SCHEMBL78393 | 0.77 | CASP3 (0.42) | CASP3CASP1CASP7CASP9BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324177-B2 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2012-12-04 | — | — | US | disclosed |
| US-20110294752-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2011-12-01 | — | — | US | disclosed |
| EP-1079824-B1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RES DEV FOUNDATION (US) | 2011-08-31 | — | — | EP | disclosed |
| US-7985435-B2 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2011-07-26 | — | — | US | disclosed |
| WO-2010116375-A1 | ISOLATED PEPTIDES FOR REGULATING APOPTOSIS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2010-10-14 | — | — | WO | disclosed |
| US-20100189824-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | ARNTZEN CHARLES J | 2010-07-29 | — | — | US | disclosed |
| EP-1601764-B1 | A CLASS OF METACASPASES | VIB VZW (BE) | 2010-04-28 | — | — | EP | disclosed |
| US-7670632-B2 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2010-03-02 | — | — | US | disclosed |
| EP-1079824-A4 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RES DEV FOUNDATION (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070271634-A1 | Preventing stress-induced apoptosis in plants | DICKMAN MARTIN B | 2007-11-22 | — | — | US | disclosed |
| WO-2002055016-A2 | INHIBITION OF NF-λB BY TRITERPENE COMPOSITIONS | RES DEV FOUNDATION (US) | 2002-07-18 | — | — | WO | disclosed |
| WO-2000052194-A9 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | IDUN PHARMACEUTICALS INC (US) | 2002-07-11 | — | — | WO | disclosed |
| US-20020090666-A1 | Methods for detecting membrane derived caspase activity and modulators thereof | IDUN PHARMACEUTICALS, INC. (US) | 2002-07-11 | — | — | US | disclosed |
| WO-2002048329-A2 | MEMBRANE DERIVED CASPASE-3, COMPOSITIONS COMPRISING THE SAME AND METHODS OF USE THEREFOR | IDUN PHARMACEUTICALS, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
| US-6399603-B1 | QUINAZOLINES; RETARDING APOPTOSIS IN CELLS; INHIBITING CLEAVAGE OF PROTEIN SUBSTRATES BY CASPASE-3; CHEMICAL AND HYDROLYTIC STABILITY | ASTRAZENECA AB (SE) | 2002-06-04 | — | — | US | disclosed |
| US-6391575-B1 | SCREENING FOR ENZYME INHIBITORS BY CONTACTING MEMBRANE FRACTION WITH SUBSTRATE IN PRESENCE AND ABSENCE OF COMPOUND, THEN COMPARING LEVELS OF SUBSTRATE TURNOVER | IDUN PHARMACEUTICALS, INC. | 2002-05-21 | — | — | US | disclosed |
| EP-1161556-A2 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | Idun Pharmaceuticals, Inc. (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1079824-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RESEARCH DEVELOPMENT FOUNDATION (a Nevada corporation) (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-2000052194-A2 | METHODS FOR DETECTING MEMBRANE DERIVED CASPASE ACTIVITY AND MODULATORS THEREOF | IDUN PHARMACEUTICALS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-1999059578-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 1999-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294752-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | OSTC, ACACA, NFATC1 | CASP3 14/4885CASP1 553/4885CASP7 79/4885 |
| US-20100189824-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | OSTC, ACACA, NFATC1 | CASP3 14/4885CASP1 553/4885CASP7 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.