Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 11/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 7/20 | 0.44 |
| ▸ | CASP1 | P29466 | 4/20 | 0.44 |
| ▸ | CASP9 | P55211 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157993 | 0.90 | CASP3 (0.57) | CASP3PTGER4CASP7CASP1CASP9 | |
| SCHEMBL4264976 | 0.83 | OPRD1 (0.55) | — | |
| SCHEMBL3366840 | 0.83 | CASP1 (0.51) | CASP3CASP7CASP1 | |
| SCHEMBL5614017 | 0.83 | MAOB (0.41) | CASP3PSMB8PSMB5MAOBMEN1 | |
| SCHEMBL2157759 | 0.81 | OPRD1 (0.52) | — | |
| SCHEMBL14968961 | 0.80 | PTGER4 (0.51) | PTGER4CTSBCTSK | |
| SCHEMBL2168561 | 0.79 | CASP3 (0.41) | CASP3PTGER4MAOBCASP7CASP1 | |
| SCHEMBL3140616 | 0.78 | CASP3 (0.62) | CASP3CTSBCTSKCASP7CASP1 | |
| SCHEMBL614741 | 0.78 | CASP3 (0.62) | CASP3CTSBCTSKCASP7CASP1 | |
| SCHEMBL4321426 | 0.78 | BACE1 (0.44) | CASP3PTGER4CASP7CASP1CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601764-B1 | A CLASS OF METACASPASES | VIB VZW (BE) | 2010-04-28 | — | — | EP | disclosed |
| US-20060029995-A1 | Novel class of metacaspases | VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW (BE) | 2006-02-09 | — | — | US | disclosed |
| EP-1601764-A2 | A CLASS OF METACASPASES | VIB vzw (BE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004081168-A2 | A CLASS OF METACASPASES | VIB VZW (BE) | 2004-09-23 | — | — | WO | disclosed |