Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 12/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.50 |
| ▸ | MET | P08581 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17884663 | 0.79 | ADAMTS5 (0.47) | MET | |
| SCHEMBL12004436 | 0.74 | HTR3E (0.54) | — | |
| SCHEMBL30020071 | 0.71 | CHRNB2 (0.89) | CHRNB2CHRNA4KDM4E | |
| SCHEMBL4355823 | 0.71 | CHRNB2 (0.89) | CHRNB2CHRNA4KDM4E | |
| SCHEMBL12006727 | 0.71 | HTR3E (0.54) | — | |
| SCHEMBL28244687 | 0.70 | CHRNB2 (0.59) | CHRNB2CHRNA4KDM4E | |
| Hydrochloric Acid SCHEMBL4057198 | 0.70 | CHRNB2 (0.86) | CHRNB2CHRNA4KDM4E | |
| SCHEMBL7924961 | 0.69 | CYP1A2 (0.42) | KDM4E | |
| SCHEMBL9980467 | 0.68 | CHRNB2 (0.53) | CHRNB2CHRNA4KDM4E | |
| SCHEMBL23346665 | 0.67 | PIK3CB (0.49) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575294-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Les Laboratoires Servier (FR) | 2019-12-04 | — | — | EP | disclosed |