Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158212 | 0.90 | CYP11B2 (0.46) | HDAC1HDAC6HDAC8HDAC5RPS6KA5 | |
| Hydrochloric Acid SCHEMBL1837642 | 0.75 | SMO (0.43) | MAPTPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1831147 | 0.72 | SMO (0.54) | MAPTNPC1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8052547 | 0.68 | RAB9A (0.59) | HDAC1MAPTNPC1RAB9AATM | |
| SCHEMBL17896717 | 0.67 | MEN1 (0.62) | HDAC1HDAC6HDAC8CYP11B1CYP11B2 | |
| SCHEMBL4958154 | 0.67 | TP53 (0.52) | HDAC1HDAC6HDAC8NPC1RAB9A | |
| SCHEMBL194305 | 0.67 | SMN1; SMN2 (0.58) | MAPTNPC1RAB9APIK3CAPIK3CB | |
| SCHEMBL103416 | 0.66 | PIK3CD (0.47) | HDAC1HDAC6HDAC8HDAC5RPS6KA5 | |
| Hydrochloric Acid SCHEMBL1831842 | 0.65 | SMO (0.43) | CYP11B1CYP11B2PIK3CBPIK3CDKCNH2 | |
| SCHEMBL17896718 | 0.65 | CYP11B2 (0.56) | CYP11B1CYP11B2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | HDAC1 695/4885HDAC6 353/4885HDAC8 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.