Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | TNKS | O95271 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31207326 | 0.84 | HRH3 (0.47) | HRH3HTR7TAAR1TNKSBRD4 | |
| SCHEMBL23630637 | 0.84 | HRH3 (0.47) | HRH3HTR7TAAR1TNKSBRD4 | |
| SCHEMBL17117158 | 0.76 | ALDH1A1 (0.54) | — | |
| SCHEMBL9440147 | 0.74 | ALDH1A1 (0.56) | — | |
| SCHEMBL13335119 | 0.70 | ALDH1A1 (0.48) | TNKSACHE | |
| SCHEMBL13681448 | 0.70 | CSF1R (0.43) | HTR7 | |
| SCHEMBL12679031 | 0.70 | HRH3 (1.00) | HRH3TAAR1TNKSBRD4BRD9 | |
| SCHEMBL14426480 | 0.70 | HTR7 (0.60) | HRH3HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL31207322 | 0.69 | HRH3 (0.46) | HRH3HTR7TAAR1 | |
| SCHEMBL23630646 | 0.69 | HRH3 (0.46) | HRH3HTR7TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019234405-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF DISORDERS ASSOCIATED WITH MUTANT RAS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2019-12-12 | — | — | WO | disclosed |