Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | WDR5 | P61964 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30410222 | 0.94 | ALDH1A1 (0.61) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL398803 | 0.94 | ALDH1A1 (0.61) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7049102 | 0.93 | GAA (0.60) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL242441 | 0.87 | GAA (0.69) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6221391 | 0.87 | GAA (0.69) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5557064 | 0.86 | WDR5 (0.66) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL861991 | 0.85 | ALDH1A1 (0.64) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28507271 | 0.83 | ALDH1A1 (0.59) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL427403 | 0.82 | SIRT6 (0.59) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10036126 | 0.82 | ALDH1A1 (0.52) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |