Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.74 |
| ▸ | DRD3 | P35462 | 6/20 | 0.74 |
| ▸ | DRD1 | P21728 | 5/20 | 0.74 |
| ▸ | DRD4 | P21917 | 5/20 | 0.74 |
| ▸ | DRD5 | P21918 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358180 | 0.85 | DRD2 (0.76) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7347704 | 0.85 | DRD2 (1.00) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL21590356 | 0.83 | DRD3 (0.62) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL28513880 | 0.82 | DRD2 (0.53) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL3128608 | 0.81 | DRD2 (0.61) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL9957718 | 0.80 | DRD2 (0.60) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL21590214 | 0.79 | DRD2 (0.76) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL22444698 | 0.78 | DRD2 (0.57) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL13416035 | 0.77 | ALDH1A1 (0.53) | DRD2DRD3MEN1KMT2ALSS | |
| SCHEMBL7667692 | 0.76 | DRD2 (0.56) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |