Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678499 | 0.86 | RAPGEF4 (0.56) | RAPGEF4CA1CA2L3MBTL1HTT | |
| SCHEMBL28458237 | 0.85 | RAPGEF4 (0.52) | RAPGEF4CA1CA2L3MBTL1PKM | |
| SCHEMBL28451886 | 0.83 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1PKM | |
| SCHEMBL28456535 | 0.83 | RAPGEF4 (0.57) | RAPGEF4CA1CA2PKMHTT | |
| SCHEMBL28449000 | 0.78 | RAPGEF4 (0.51) | RAPGEF4CA1CA2L3MBTL1PKM | |
| SCHEMBL1365792 | 0.78 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1PKM | |
| SCHEMBL28487419 | 0.76 | RAPGEF4 (0.49) | RAPGEF4CA1CA2L3MBTL1POLB | |
| SCHEMBL28453157 | 0.76 | HTR6 (0.58) | RAPGEF4CA1CA2L3MBTL1KMT2A | |
| SCHEMBL30977550 | 0.76 | CYP2A6 (0.50) | RAPGEF4CA1CA2L3MBTL1PKM | |
| SCHEMBL30877392 | 0.75 | RAPGEF4 (0.48) | RAPGEF4CA1CA2L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |