Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29289961 | 0.82 | PARP1 (0.49) | PARP1KDM4EALDH1A1CYP1A2MAPT | |
| SCHEMBL27601273 | 0.81 | PARP1 (0.48) | PARP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL15966073 | 0.80 | PARP1 (0.52) | PARP1KDM4EALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL2160307 | 0.79 | PARP1 (0.51) | PARP1KDM4EALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL19539578 | 0.78 | ALDH1A1 (0.47) | PARP1KDM4EALDH1A1HTTTDP1 | |
| SCHEMBL7218347 | 0.77 | PARP1 (0.50) | PARP1KDM4EALDH1A1L3MBTL1POLB | |
| SCHEMBL28019213 | 0.77 | PKM (0.45) | GCKKDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL21590248 | 0.76 | TSHR (0.49) | KDM4EALDH1A1L3MBTL1HTTPOLB | |
| SCHEMBL22018876 | 0.76 | KDM4E (0.58) | KDM4EALDH1A1L3MBTL1CYP1A2MAPT | |
| SCHEMBL28805406 | 0.75 | KDM4E (0.41) | PARP1KDM4EALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |