Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30969090 | 0.86 | BACE1 (0.43) | CHRNA7MPOBACE1CYP11B1CYP11B2 | |
| SCHEMBL2259723 | 0.83 | LTA4H (0.53) | BACE1 | |
| SCHEMBL9694096 | 0.83 | MPO (0.48) | CHRNA7MPOCYP11B1CYP11B2CYP1A2 | |
| Ammonia Solution, Strong SCHEMBL4936578 | 0.82 | BACE1 (0.61) | BACE1CYP11B1CYP11B2CYP1A2CYP2A6 | |
| SCHEMBL4418570 | 0.80 | HTT (0.49) | CHRNA7MPOCYP11B1CYP11B2CYP1A2 | |
| Hydrochloric Acid SCHEMBL11398017 | 0.79 | HTT (0.47) | CHRNA7MPOCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL27836688 | 0.79 | HTT (0.51) | CHRNA7CYP11B1CYP11B2CYP1A2CYP2D6 | |
| SCHEMBL3962268 | 0.78 | DHFR (0.60) | — | |
| SCHEMBL30612271 | 0.77 | CHRNA7 (0.46) | CHRNA7MPOCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL9665011 | 0.77 | CHRNA7 (0.46) | CHRNA7MPOCYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807273-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2021-04-21 | — | — | EP | claimed |
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | claimed |