Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.42 |
| ▸ | PIM1 | P11309 | 5/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 5/20 | 0.41 |
| ▸ | PLK4 | O00444 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | PRKACA | P17612 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29836569 | 1.00 | DYRK1A (0.42) | DYRK1APIM1DYRK2DYRK1BCDC7 | |
| SCHEMBL23762247 | 0.92 | MAPK14 (0.40) | DYRK1APIM1CDC7PLK4CHEK1 | |
| SCHEMBL29836476 | 0.81 | MET (0.41) | DYRK1APIM1CDC7CHEK1ROCK2 | |
| SCHEMBL21593087 | 0.81 | MET (0.41) | DYRK1APIM1CDC7CHEK1ROCK2 | |
| SCHEMBL29836539 | 0.81 | MET (0.44) | DYRK1APIM1DYRK2DYRK1BCDC7 | |
| SCHEMBL21591789 | 0.81 | MET (0.44) | DYRK1APIM1DYRK2DYRK1BCDC7 | |
| SCHEMBL21591757 | 0.78 | DYRK1A (0.39) | DYRK1APIM1DYRK2DYRK1BCDC7 | |
| SCHEMBL29836429 | 0.78 | DYRK1A (0.39) | DYRK1APIM1DYRK2DYRK1BCDC7 | |
| SCHEMBL21591759 | 0.76 | DYRK1A (0.44) | DYRK1APIM1DYRK2DYRK1BCDC7 | |
| SCHEMBL29836588 | 0.76 | DYRK1A (0.44) | DYRK1APIM1DYRK2DYRK1BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807273-B1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2022-08-03 | — | — | EP | claimed |
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-08-19 | — | — | US | claimed |
| EP-3807273-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2021-04-21 | — | — | EP | claimed |
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | claimed |
| EP-3807273-B1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2022-08-03 | — | — | EP | disclosed |
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-08-19 | — | — | US | disclosed |
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-08-19 | — | — | US | disclosed |
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | ROCK1, ROCK2, RHOA | DYRK1A 1692/4885PIM1 1177/4885DYRK2 1350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.